Fadogia Agrestis, also known as Fadogia cienkowskii, is a Nigerian flowering plant used traditionally as a natural aphrodisiac for men. The roots of the Fadogia plant have a history of traditional use in Nigerian herbal medicine. Recently, it’s gained popularity as a supplement, often combined with Tongkat Ali, to potentially enhance testosterone and male fertility.
In July 2023, a study conducted by scientists from the Pharmacology and Toxicology Department at the University of Jos in Nigeria revealed significant adverse effects on kidneys and liver in rats following a 40-day administration of Fadogia extract.
These findings have sparked concerns within the health and nutrition communities in the United States and the United Kingdom due to the increasing number of reported acute and adverse side effects associated with Fadogia Agrestis supplements.
Does Fadogia affect kidney and liver?
Fadogia was found to affect both the kidney and liver. A recent study by scientists from the University of Jos, Nigeria, revealed severe inflammation of the kidneys and liver tissue necrosis at varying doses based on body weight (50 mg/kg, 100 mg/kg, and 200 mg/kg) after 40 days. This study was conducted as part of a toxicology and safety assessment published in Scientific African in July 2023.
Effects of Fadogia on kidney
In a July 2023 toxicology study, the use of 50 mg/kg of Fadogia root extract resulted in significant inflammation of kidney cells in albino rats, confirming kidney damage. Similarly, at a higher dose of 100 mg/kg, the study also revealed substantial inflammation of red blood cells within the tissue and a reduction in interstitial spaces caused by Fadogia Agrestis.
Effects of Fadogia on liver
The study revealed significant findings regarding the effects of Fadogia extract on albino rats. Rats treated with 50 mg/kg of the extract exhibited ballooning necrosis, while those treated with 100 mg/kg displayed extensive tissue degeneration (necrosis). Moreover, rats receiving 200 mg/kg of the extract also experienced increased ballooning necrosis.
These findings provide compelling evidence of Fadogia’s harmful impact on the liver, even at relatively low dosages, resulting in irreversible tissue death (necrosis). Necrosis occurs when organ tissues receive insufficient blood flow, and when it affects large areas, it’s referred to as gangrene. This suggests that prolonged use of Fadogia may potentially lead to gangrene and liver failure.
Natural supplements like Fadogia have gained recent popularity, with well-known brands like Momentous Fadogia often endorsed by celebrity doctor Andrew Huberman.
However, it’s crucial for users to exercise caution due to the documented harmful effects of Fadogia on kidney and liver functions. The tissue cell damage caused by Fadogia remains a significant concern among herbal enthusiasts.
Even if you don’t experience immediate side effects from Fadogia, the long-term impact on your liver and kidneys is a genuine and undeniable concern.